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    Modafinil 400 mg daily
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    Anabolic steroids for diet
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    Background: The aim of this study was to investigate the effect of anabolic steroids on kidneys in bodybuilders. Two-year clinical data are presented and renal function was measured during a controlled, supervised, four month period.

    Materials and Methods: A total of 29 bodybuilders with a body mass index 20–25.0 kg/m2 (n = 14) and 28 matched sedentary controls of similar age (age range 20–45) were studied. Body composition (BMI, BMI-adjusted BSA, lean body mass, percent body fat, fat mass, and total body water adjusted for the sum of both BMI and BSA) and blood markers of kidney function were also evaluated at baseline and after four months of drug therapy. A urine specimen was collected during each visit and analyzed for drugs using the GC/MS/MS method.

    Results: During the study, there was a significant difference between the groups in both plasma and urine albumin (p trend <0.05), albumin/creatinine ratio (p trend =0.034), urinary calcium (p trend <0.001), sodium (p trend <0.001), creatinine level (p trend <0.005) and albumin/creatinine ratio (p trend <0.05) at baseline. After the four-month period a significant reduction was noted in the creatinine level with creatinine clearance was increased from 34.4±13.2 to 37.3±12.2 mL/min/1.73 m2, indicating a fall in renal tract function. Plasma corticosterone also decreased significantly in the bodybuilders (p trend =0.047) and their urinary creatinine and glucuronides increased (p trend =0.008) while the urinary calcium decreased (p trend =0.027).

    Conclusion: Anabolic steroid administration to bodybuilders results in a fall in both urinary creatinine and urinary albumin but no change in urinary calcium. There is a small decrease in urinary magnesium but no change in renal functioning.

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